Article
Collocation of androgen receptor gene mutations in prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2001
Buchanan G, Greenberg N M, Scher H I, Harris J M, Marshall V R, Tilley W D
Abstract excerpt
Consistent with both the development of the normal prostate gland and prostate tumorigenesis being dependent on testicular androgens, targeting the androgen-signaling axis (i.e., androgen ablation therapy) remains the predominant treatment regime for patients with metastatic prostate cancer. Although there is a very good initial response to androgen ablation, these treatments are essentially palliative. Recent...
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