Identification of two novel, kinase‐deficient variants of discoidin domain receptor 1: differential expression in human colon cancer cell lines

Abstract excerpt

ABSTRACT Discoidin domain receptor 1 belongs to a subfamily of tyrosine kinase receptors activated by various types of collagen. Alternative splicing in the juxtamembrane region of the receptor results in the insertion of 37 amino acids. Here we used primer flanking the juxtamembrane region to search for additional isoforms. From human colon carcinoma Colo 206F cells, we identified two novel isoforms, DDR1d and...

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