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Article

Equivalent binding of wild-type lipoprotein lipase (LPL) and S447X-LPL to GPIHBP1, the endothelial cell LPL transporter.

Biochimica et biophysica acta - 1 Jul 2014

Turlo Kirsten, Leung Calvin S, Seo Jane J, Goulbourne Chris N, Adeyo Oludotun, Gin Peter, Voss Constance, Bensadoun André, Fong Loren G, Young Stephen G, Beigneux Anne P

Abstract excerpt

The S447X polymorphism in lipoprotein lipase (LPL), which shortens LPL by two amino acids, is associated with low plasma triglyceride levels and reduced risk for coronary heart disease. S447X carriers have higher LPL levels in the pre- and post-heparin plasma, raising the possibility that the S447X polymorphism leads to higher LPL levels within capillaries. One potential explanation for increased amounts of LPL...

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Source

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Identifiers

PMID: 24704550
DOI: 10.1016/j.bbalip.2014.03.011
PMCID: PMC4212522

Genes

LPL
GPIHBP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Equivalent binding of wild-type lipoprotein lipase (LPL) and S447X-LPL to GPIHBP1, the endothelial cell LPL transporter.PMID 24704550Read ↗

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