Article
Characterization of an apolipoprotein E3 variant (Arg 145-->His) associated with mild hypertriglyceridemia.
Annals of clinical and laboratory science - 1 Apr 2001
Hidaka H, Tozuka M, Hidaka E, Yamauchi K, Ota H, Honda T, Katsuyama T
Abstract excerpt
In a proband (21-yr-old female), we previously identified an apolipoprotein (apo) E variant, apoE3 (Arg 145-->His), with an isoelectric point midway between apoE3 and apoE2. ApoE gene analysis of 4 of the proband's kin indicated that 3 possess the same variant. All 4 had a high concentration of apoE in plasma, while 3 of 4 had hypertriglyceridemia. In the proband (who had no hypertriglyceridemia), most apoE was...
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