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Article

Characterization of a new apolipoprotein E5 variant detected in two French-Canadian subjects.

Journal of lipid research - 1 Apr 1991

Mailly F, Xu C F, Xhignesse M, Lussier-Cacan S, Talmud P J, Davignon J, Humphries S E, Nestruck A C

Abstract excerpt

We have found a novel apoE5 mutation, using isoelectric focusing (IEF), in two apparently unrelated French-Canadian subjects. Co-dominant inheritance was demonstrated in the family of the first proband, a healthy male subject. The presence of the apoE5 form was not associated with lipid abnormalities or cardiovascular disease in this family. The second proband was a hyperlipidemic female patient suffering from...

Topics

Adult
Alleles
Amino Acid Sequence
Apolipoproteins E
Base Sequence
Epitopes
Female
Genetic Variation
Humans
Hyperlipidemia, Familial Combined
Lipoproteins, VLDL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Molecular Sequence Data

Mutation

Pedigree

Source

Identifiers

PMID: 1713245

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1713245-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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