Article
Lipoprotein profiles in a family with two mutants of apolipoprotein E: possible association with hypertriglyceridaemia but not with dysbetalipoproteinaemia.
Clinical science (London, England : 1979) - 1 Mar 1994
Zhao S P, Van den Maagdenberg A M, Vroom T F, Van 't Hooft F M, Gevers Leuvens J A, Havekes L M, Frants R R, Van der Laarse A, Smelt A H
Abstract excerpt
1. The plasma lipoprotein profiles of eight members of a Dutch pedigree spanning three generations where two rare apolipoprotein E mutants, APOE*3(Cys-112-->Arg; Arg-251-->Gly) and APOE*2(Val-236-->Glu), segregate were analysed to determine whether the APOE mutants were associated with dyslipidaemia. 2. The proband, a 51-year-old Caucasian male, was a carrier of APOE*3(Cys-112-->Arg; Arg-251-->Gly) and his spouse...
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