Article
Lack of association of CCR2-64I and CCR5-Delta 32 with type 1 diabetes and latent autoimmune diabetes in adults.
Human immunology - 1 Jun 2003
Gambelunghe Giovanni, Ghaderi Mehran, Brozzetti Annalisa, Del Sindaco Paola, Gharizadeh Babeck, Nyren Paul, Hjelmström Peter, Nikitina-Zake Liene, Sanjeevi Carani B, Falorni Alberto
Abstract excerpt
It is well known that type 1 diabetes mellitus (T1DM) is a complex genetic disease resulting from the autoimmune destruction of pancreatic beta cells. Several genes have been associated with susceptibility and/or protection for T1DM, but the disease risk is mostly influenced by genes located in the class II region of the major histocompatibility complex. The attraction of leukocytes to tissues is essential for...
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