Human Coxsackie-Adenovirus Receptor Is Colocalized With Integrins α _v β ₃ and α _v β ₅ on the Cardiomyocyte Sarcolemma and Upregulated in Dilated Cardiomyopathy

Abstract excerpt

BACKGROUND: The coxsackievirus and adenovirus receptor (CAR) was identified as a common cellular receptor for both viruses, but its biological and pathogenic relevance is uncertain. Knowledge of CAR localization in the human cardiovascular system is limited but important with respect to CAR-dependent viral infections and gene transfer using CAR-dependent viral vectors. METHODS AND RESULTS: Explanted failing...

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