Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: Direct correlation with clinical retinopathy of prematurity

Abstract excerpt

Retinopathy of prematurity is a blinding disease, initiated by lack of retinal vascular growth after premature birth. We show that lack of insulin-like growth factor I (IGF-I) in knockout mice prevents normal retinal vascular growth, despite the presence of vascular endothelial growth factor, important to vessel development. In vitro, low levels of IGF-I prevent vascular endothelial growth factor-induced...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Pregnancy and preeclampsia studies
• Share to Retinal Diseases and Treatments
• Share to Retinopathy of Prematurity Studies