Article
Lack of association between insulin-like growth factor I receptor G(+3174)A polymorphism and retinopathy of prematurity.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie - 1 Aug 2006
Balogh Adám, Derzbach László, Vannay Adám, Vásárhelyi Barna
Abstract excerpt
BACKGROUND: Retinopathy of prematurity (ROP) is a potentially blinding eye disorder that affects premature infants. Insulin-like growth factor I (IGF-I) has been established as being necessary for vascular growth in the neonatal retina. Low IGF-I levels during the early postnatal days have been found to be predictive for ROP. The effects of IGF-I are mediated through IGF-I receptors (IGF-IR), which, in turn,...
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