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Homologous-pairing activity of the human DNA-repair proteins Xrcc3⋅Rad51C

1 May 2001

Abstract excerpt

The human Xrcc3 protein is involved in the repair of damaged DNA through homologous recombination, in which homologous pairing is a key step. The Rad51 protein is believed to be the only protein factor that promotes homologous pairing in recombinational DNA repair in mitotic cells. In the brain, however, Rad51 expression is extremely low, whereas XRCC3, a human homologue of Saccharomyces cerevisiae RAD57 that...

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PMID: 11331762
DOI: 10.1073/pnas.091603098

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