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Article

Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations.

Journal of neurochemistry - 1 May 2001

Kawamata H, McLean P J, Sharma N, Hyman B T

Abstract excerpt

alpha-Synuclein is a major component of Lewy bodies, a neuropathological feature of Parkinson's disease. Two alpha-synuclein mutations, Ala53Thr and Ala30Pro, are associated with early onset, familial forms of the disease. Recently, synphilin-1, a protein found to interact with alpha-synuclein by yeast two hybrid techniques, was detected in Lewy bodies. In this study we report the interaction of alpha-synuclein...

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Identifiers

PMID: 11331421
DOI: 10.1046/j.1471-4159.2001.00301.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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