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Article

Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease.

Brain : a journal of neurology - 1 Jul 2014

Winslow Ashley R, Moussaud Simon, Zhu Liya, Post Kathryn L, Post Katherine L, Dickson Dennis W, Berezovska Oksana, McLean Pamela J

Abstract excerpt

A growing number of PSEN1 mutations have been associated with dementia with Lewy bodies and familial Alzheimer's disease with concomitant α-synuclein pathology. The objective of this study was to determine if PSEN1 plays a direct role in the development of α-synuclein pathology in these diseases. Using mass spectrometry, immunoelectron microscopy and fluorescence lifetime image microscopy based on Forster...

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Source

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Identifiers

PMID: 24860142
DOI: 10.1093/brain/awu119
PMCID: PMC4065023

Genes

PSEN1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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