Article
Increased frequency of alleles associated with elevated tumor necrosis factor-alpha levels in children with Kawasaki disease.
Pediatric research - 1 May 2001
Quasney M W, Bronstein D E, Cantor R M, Zhang Q, Stroupe C, Shike H, Bastian J F, Matsubara T, Fujiwara M, Akimoto K, Newburger J W, Burns J C
Abstract excerpt
Genetic polymorphisms influence the magnitude of the cytokine response after an inflammatory stimulus. To determine whether such polymorphisms might play a role in Kawasaki disease (KD), we analyzed white and Japanese children with KD and control populations for two polymorphic loci in which the A allele is associated with high tumor necrosis factor-alpha secretion. The lymphotoxin-alpha+250 A/A genotype was...
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