Article
Pro-inflammatory cytokine single nucleotide polymorphisms in Kawasaki disease.
International journal of rheumatic diseases - 1 May 2018
Assari Raheleh, Aghighi Yahya, Ziaee Vahid, Sadr Maryam, Rahmani Farzaneh, Rezaei Arezou, Sadr Zeinab, Moradinejad Mohammad Hassan, Raeeskarami Seyed Reza, Rezaei Nima
Abstract excerpt
AIM: Kawasaki disease (KD) is a systemic vasculitis of children associated with cardiovascular sequelae. Proinflammatory cytokines play a major role in KD pathogenesis. However, their role is both influenced and modified by regulatory T-cells. IL-1 gene cluster, IL-6 and TNF-α polymorphisms have shown significant associations with some vasculitides. Herein we investigated their role in KD. METHODS: Fifty-five...
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