Article
Target site modifications and efflux phenotype in clinical isolates of Streptococcus pneumoniae from Hong Kong with reduced susceptibility to fluoroquinolones.
The Journal of antimicrobial chemotherapy - 1 May 2001
Ho P L, Yam W C, Que T L, Tsang D N, Seto W H, Ng T K, Ng W S
Abstract excerpt
Ciprofloxacin-susceptible (n = 7) and -resistant (MIC >or=4 mg/L) (n = 15) clinical isolates of Streptococcus pneumoniae from diverse sources in Hong Kong were studied for target site modifications and efflux phenotype. Reserpine-inhibited efflux of ciprofloxacin and/or levofloxacin was common in both susceptible and non-susceptible isolates. The ParC substitutions K137N and/or S79F or Y were associated with...
Topics
- Amino Acid Substitution
- Anti-Infective Agents
- Bacterial Proteins
- Biological Transport
- Drug Resistance, Microbial
- Fluoroquinolones
- Humans
- Microbial Sensitivity Tests
- Mutation
- Phenotype
- Streptococcus pneumoniae