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Article

Ubiquitination of p53 at multiple sites in the DNA-binding domain.

Molecular cancer research : MCR - 1 Jan 2006

Chan Wan Mui, Mak Man Chi, Fung Tsz Kan, Lau Anita, Siu Wai Yi, Poon Randy Y C

Abstract excerpt

The tumor suppressor p53 is negatively regulated by the ubiquitin ligase MDM2. The MDM2 recognition site is at the NH2-terminal region of p53, but the positions of the actual ubiquitination acceptor sites are less well defined. Lysine residues at the COOH-terminal region of p53 are implicated as sites for ubiquitination and other post-translational modifications. Unexpectedly, we found that substitution of the...

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Source

Identifiers

PMID: 16446403
DOI: 10.1158/1541-7786.MCR-05-0097

Genes

MDM2

Provenance

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Related research

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Ubiquitination of p53 at multiple sites in the DNA-binding domain.PMID 16446403Read ↗

Mdm2 mutant defective in binding p300 promotes ubiquitination but not degradation of p53: evidence for the role of p300 in integrating ubiquitination and proteolysis.Semantic proximity Read ↗

Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo.Semantic proximity Read ↗

MDM2 can promote the ubiquitination, nuclear export, and degradation of p53 in the absence of direct binding.Semantic proximity Read ↗

Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53.Semantic proximity Read ↗

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.Semantic proximity Read ↗

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity.Semantic proximity Read ↗

Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents.Semantic proximity Read ↗

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation.Semantic proximity Read ↗

C-terminal ubiquitination of p53 contributes to nuclear export.Semantic proximity Read ↗

Sensitivity of p53 lysine mutants to ubiquitin-directed degradation targeted by human papillomavirus E6.Semantic proximity Read ↗

Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction.Semantic proximity Read ↗

MDM2 Is a Negative Regulator of p21 , Independent of p53Semantic proximity Read ↗

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