Article
A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population.
Nature genetics - 1 May 2001
Laitinen T, Daly M J, Rioux J D, Kauppi P, Laprise C, Petäys T, Green T, Cargill M, Haahtela T, Lander E S, Laitinen L A, Hudson T J, Kere J
Abstract excerpt
The genetics of asthma and atopy have been difficult to determine because these diseases are genetically heterogeneous and modified by environment. The pedigrees in our study (n=86) originate in eastern central Finland (Kainuu province). According to census records, this region had only 200 households (2,000 inhabitants) in the mid sixteenth to mid seventeenth centuries. The current population of 100,000...
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