Article
Characterization of a common susceptibility locus for asthma-related traits.
Science (New York, N.Y.) - 9 Apr 2004
Laitinen Tarja, Polvi Anne, Rydman Pia, Vendelin Johanna, Pulkkinen Ville, Salmikangas Paula, Mäkelä Siru, Rehn Marko, Pirskanen Asta, Rautanen Anna, Zucchelli Marco, Gullstén Harriet, Leino Marina, Alenius Harri, Petäys Tuula, Haahtela Tari, Laitinen Annika, Laprise Catherine, Hudson Thomas J, Laitinen Lauri A, Kere Juha
Abstract excerpt
Susceptibility to asthma depends on variation at an unknown number of genetic loci. To identify susceptibility genes on chromosome 7p, we adopted a hierarchical genotyping design, leading to the identification of a 133-kilobase risk-conferring segment containing two genes. One of these coded for an orphan G protein-coupled receptor named GPRA (G protein-coupled receptor for asthma susceptibility), which showed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.