Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of insulin-stimulated glycogen synthesis by Src Homology Phosphatase 2.

Molecular and cellular endocrinology - 25 Apr 2001

Ouwens D M, van der Zon G C, Maassen J A

Abstract excerpt

We have examined the requirement of the protein tyrosine phosphatase Src Homology Phosphatase 2 (SHP2) for insulin-stimulated glycogen synthesis. To this end, 3T3L1 fibroblasts were stably transfected with either wild type or a catalytically inactive C463A-mutant of SHP2, and analysed for insulin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Glycogen
Share to Insulin Receptor Substrate Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Phosphatase 2

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 6

Share to Receptor, Insulin

Share to src Homology Domains

Source

Identifiers

PMID: 11325523
DOI: 10.1016/s0303-7207(01)00389-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11325523-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of insulin-stimulated glycogen synthesis by Src Homology Phosphatase 2.PMID 11325523Read ↗

Tyrosine phosphorylation-dependent and -independent role of Shc in the regulation of IGF-1-induced mitogenesis and glycogen synthesis.Semantic proximity Read ↗

Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues.Semantic proximity Read ↗

Protein tyrosine phosphatases as stimulators and inhibitors of insulin signalling: possible candidates for insulin resistance.Semantic proximity Read ↗

Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif.Semantic proximity Read ↗

GTK tyrosine kinase-induced alteration of IRS-protein signalling in insulin producing cells.Semantic proximity Read ↗

Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases.Semantic proximity Read ↗

Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes.Semantic proximity Read ↗

STAT3 sensitizes insulin signaling by negatively regulating glycogen synthase kinase-3 beta.Semantic proximity Read ↗

The stimulation of pp42mapkinase by insulin does not correlate with its metabolic actions in cells overexpressing mutant insulin receptors.Semantic proximity Read ↗

The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth.Semantic proximity Read ↗

Regulation and functions of the glycogen synthase kinase-3 subfamily.Semantic proximity Read ↗

Impact of natural IRS-1 mutations on insulin signals: mutations of IRS-1 in the PTB domain and near SH2 protein binding sites result in impaired function at different steps of IRS-1 signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.