Article
Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression.
Brain research. Molecular brain research - 10 Nov 1999
Donovan D M, Miner L L, Perry M P, Revay R S, Sharpe L G, Przedborski S, Kostic V, Philpot R M, Kirstein C L, Rothman R B, Schindler C W, Uhl G R
Abstract excerpt
Polygenic factors play important roles in animal models of substance abuse and susceptibility to dopaminergic neurodegeneration. Genetic factors are also likely to contribute to the etiology of human drug abuse disorders, and may alter human vulnerabilities to Parkinsonian neurodegeneration. The dopamine transporter (DAT; SLC6A3) is densely expressed by the dopaminergic midbrain neurons that play central roles in...
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