Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dynamic properties of the Ras switch I region and its importance for binding to effectors.

Proceedings of the National Academy of Sciences of the United States of America - 24 Apr 2001

Spoerner M, Herrmann C, Vetter I R, Kalbitzer H R, Wittinghofer A

Abstract excerpt

We have investigated the dynamic properties of the switch I region of the GTP-binding protein Ras by using mutants of Thr-35, an invariant residue necessary for the switch function. Here we show that these mutants, previously used as partial loss-of-function mutations in cell-based assays, have a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Conserved Sequence
Share to Crystallography, X-Ray
Share to Isomerism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligands

Share to Magnesium

Share to Magnetic Resonance Spectroscopy

Share to Proto-Oncogene Proteins p21(ras)

Share to Threonine

Source

Open in PubMed Open full text

Identifiers

PMID: 11320243
DOI: 10.1073/pnas.081441398
PMCID: PMC33143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11320243-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dynamic properties of the Ras switch I region and its importance for binding to effectors.PMID 11320243Read ↗

Perturbation of the conformational equilibria in Ras by selective mutations as studied by 31P NMR spectroscopy.Semantic proximity Read ↗

Dynamically encoded reactivity of Ras enzymes: opening new frontiers for drug discovery.Semantic proximity Read ↗

Improved binding of raf to Ras.GDP is correlated with biological activity.Semantic proximity Read ↗

Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras.Semantic proximity Read ↗

What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf.Semantic proximity Read ↗

Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf.Semantic proximity Read ↗

NMR assignment of Cdc42(T35A), an active Switch I mutant of Cdc42.Semantic proximity Read ↗

The distinct conformational dynamics of K-Ras and H-Ras A59G.Semantic proximity Read ↗

Structural consequences of site-directed mutagenesis in flexible protein domains: NMR characterization of the L(55,56)S mutant of RhoGDI.Semantic proximity Read ↗

Allosteric site variants affect GTP hydrolysis on RASSemantic proximity Read ↗

Solid-state 31P NMR spectroscopy of precipitated guanine nucleotide-binding protein Ras in complexes with its effector molecules Raf kinase and RalGDS.Semantic proximity Read ↗

Dynamic polymorphism of Ras observed by single molecule FRET is the basis for molecular recognition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.