Article
Sequence of Crm1/exportin 1 mutant alleles reveals critical sites associated with multidrug resistance.
Current genetics - 1 Feb 2001
Carobbio S, Realini C, Norbury C J, Toda T, Cavalli F, Spataro V
Abstract excerpt
We have previously shown that genes involved in a novel pathway of multidrug resistance (MDR) in the fission yeast Schizosaccharomyces pombe are functionally conserved in human cells (V. Spataro et al. (1997) J Biol Chem 272: 30470-30475). The human homologue of one of these genes, hCRM1, has recently been identified and found to function in nucleocytoplasmic export, a process which controls the subcellular...
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