Article
A polymorphism in the 5' untranslated region and a Met229-->Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus.
Diabetologia - 1 Mar 2001
Mori H, Okazawa H, Iwamoto K, Maeda E, Hashiramoto M, Kasuga M
Abstract excerpt
AIMS/HYPOTHESIS: The cumulative effects of several thrifty factors could contribute to the pathogenesis of Type II (non-insulin-dependent) diabetes mellitus. We screened the human UCP1 gene (UCP1) for polymorphisms associated with susceptibility to Type II diabetes. METHODS: By using PCR and sing...
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