Article
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.
Oncogene - 22 Feb 2001
Forgacs E, Wren J D, Kamibayashi C, Kondo M, Xu X L, Markowitz S, Tomlinson G E, Muller C Y, Gazdar A F, Garner H R, Minna J D
Abstract excerpt
RepX represents a new informatics approach to probe the UniGene database for potentially polymorphic repeat sequences in the open reading frame (ORF) of genes, 56% of which were found to be actually polymorphic. We now have performed mutational analysis of 17 such sites in genes not found to be polymorphic (<0.03 frequency) in a large panel of human cancer genomic DNAs derived from 31 lung, 21 breast, seven...
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