Article
Characterization of Inherited Differences in Transcription of the Human Integrin alpha 2 Gene.
The Journal of biological chemistry - 29 Jun 2001
Jacquelin B, Rozenshteyn D, Kanaji S, Koziol J A, Nurden A T, Kunicki T J
Abstract excerpt
Inherited, single-base substitutions are found at only two positions, C(-)52T and C(-)92G, within the proximal 5'-regulatory region (within -1096 to +48) of the human integrin alpha(2) gene. We recently reported that the T(-)52 substitution results in decreased binding of transcription factor Sp1 to adjacent binding sites, decreased transcription of the alpha(2) gene, and reduced densities of platelet...
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