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Article

DNA tests in prolific sheep from eight countries provide new evidence on origin of the Booroola (FecB) mutation.

Biology of reproduction - 1 Jun 2002

Davis George H, Galloway Susan M, Ross Ian K, Gregan Scott M, Ward Jamie, Nimbkar Bon V, Ghalsasi Pradip M, Nimbkar Chanda, Gray G Douglas, Subandriyo, Inounu Ismeth, Tiesnamurti Bess, Martyniuk Elzbieta, Eythorsdottir Emma, Mulsant Philippe, Lecerf Frederic, Hanrahan James P, Bradford G Eric, Wilson Theresa

Abstract excerpt

Recent discoveries that high prolificacy in sheep carrying the Booroola gene (FecB) is the result of a mutation in the BMPIB receptor and high prolificacy in Inverdale sheep (FecX(I)) is the result of a mutation in the BMP15 oocyte-derived growth factor gene have allowed direct marker tests to be developed for FecB and FecX(I). These tests were carried out in seven strains of sheep (Javanese, Thoka, Woodlands,...

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Source

Identifiers

PMID: 12021074
DOI: 10.1095/biolreprod66.6.1869

Genes

BMP15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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DNA tests in prolific sheep from eight countries provide new evidence on origin of the Booroola (FecB) mutation.PMID 12021074Read ↗

Investigation of the Booroola (FecB) and Inverdale (FecX(I)) mutations in 21 prolific breeds and strains of sheep sampled in 13 countries.Semantic proximity Read ↗

Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells.Semantic proximity Read ↗

The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1 B (BMPR1B) gene.Semantic proximity Read ↗

Mechanisms of action of the principal prolific genes and their application to sheep production.Semantic proximity Read ↗

Screening of indigenous goats for prolificacy associated DNA markers of sheep.Semantic proximity Read ↗

Polymorphism of fecundity genes (FecB, FecX, and FecG) in the Indian Bonpala sheep.Semantic proximity Read ↗

FecX Bar a Novel BMP15 mutation responsible for prolificacy and female sterility in Tunisian Barbarine Sheep.Semantic proximity Read ↗

Prolificacy genes in sheep: the French genetic programmes.Semantic proximity Read ↗

Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Mérino ewes.Semantic proximity Read ↗

Mutation in BMPR-IB gene is associated with litter size in Iranian Kalehkoohi sheep.Semantic proximity Read ↗

Investigation of prolific sheep from UK and Ireland for evidence on origin of the mutations in BMP15 (FecX(G), FecX(B)) and GDF9 (FecG(H)) in Belclare and Cambridge sheep.Semantic proximity Read ↗

The Booroola mutation in sheep is associated with an alteration of the bone morphogenetic protein receptor-IB functionality.Semantic proximity Read ↗

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