Article
Long-term persistence of cellular immunity to Oka vaccine virus induced by pernasal co-administration with Escherichia coli enterotoxin in mice.
Vaccine - 30 Apr 2001
Kamiya N, Asano Y, Yoshino J, Sasaki K, Honma Y, Kawase H, Yokochi T, Shiraki K, Tsuji T
Abstract excerpt
A mutant of Escherichia coli enterotoxin induced cellular immunity to a live varicella vaccine (the Oka strain) as a mucosal adjuvant in mice. The persistence of this cellular immunity was investigated. A commercially available live Oka vaccine virus and toxin were administered once simultaneously via the nasal route, in mice. Ten or 12 months later, a delayed-type hypersensitivity to the vaccine virus was...
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