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Mutant Escherichia coli enterotoxin as a mucosal adjuvant induces specific Th1 responses of CD4+ and CD8+ T cells to nasal killed-bacillus calmette-guerin in mice.

Vaccine - 24 Apr 2006

Takahashi Hiroki, Sasaki Keiko, Takahashi Miyuki, Shigemori Naoko, Honda Shyunichi, Arimitsu Hideyuki, Ochi Sadayuki, Ohara Naoya, Tsuji Takao

Abstract excerpt

On single nasal immunization of mice with killed-bacillus calmette-guerin (BCG) plus a mutant Escherichia coli enterotoxin, delayed-type hypersensitivity was induced and BCG-infection decreased. Spleen cells, particularly CD4+ T cells among them produced IL-2, IFNgamma and TNFalpha in response to the killed-BCG or purified protein derivatives. CD8+ T cells including cytotoxic T lymphocytes produced IFNgamma and...

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Source

Identifiers

PMID: 16556474
DOI: 10.1016/j.vaccine.2006.01.060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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