Article
A mutant of Escherichia coli enterotoxin inducing a specific Thl-type of T cells to varicella-zoster vaccine enhances the production of IL-12 by IFNgamma-stimulated macrophages.
Vaccine - 1 May 2006
Shimizu Toshiyasu, Sasaki Keiko, Kato Michio, Arimitsu Hideyuki, Ochi Sadayuki, Yano Tomomasa, Oguma Keiji, Yokochi Takashi, Tsuji Takao
Abstract excerpt
A mutant of Escherichia coli enterotoxin induces specific Thl-type T cells to varicella-zoster vaccine. The mutant increased IL-12p40, TNFalpha and nitric oxide production by IFNgamma-stimulated bone marrow macrophages but cholera toxin did not. Anti-TNFalpha antibodies blocked its stimulation of IL-12p40 production but iNOS inhibitor did not. IL-12p40 and IL-12p35 production was stimulated at the level of mRNA...
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