Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations.

doi:10.1054/bjoc.2001.1728

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Article

Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations.

British journal of cancer - 20 Apr 2001

Nordsmark M, Alsner J, Keller J, Nielsen O S, Jensen O M, Horsman M R, Overgaard J

Abstract excerpt

Clinical and experimental studies have suggested that tumour hypoxia is associated with poor treatment outcome and that loss of apoptotic potential may play a role in malignant progression of neoplastic cells. The tumour suppressor gene p53 induces apoptosis under certain conditions and microenvi...

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