Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations.

doi:10.1054/bjoc.2001.1728

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Article

Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations.

British journal of cancer - 20 Apr 2001

Nordsmark M, Alsner J, Keller J, Nielsen O S, Jensen O M, Horsman M R, Overgaard J

Abstract excerpt

Clinical and experimental studies have suggested that tumour hypoxia is associated with poor treatment outcome and that loss of apoptotic potential may play a role in malignant progression of neoplastic cells. The tumour suppressor gene p53 induces apoptosis under certain conditions and microenvironmental tumour hypoxia may select for mutant tumour cells with diminished apoptotic potential due to lack of p53...

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