Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial.

doi:10.1016/S0140-6736(04)17273-5

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Article

Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial.

Lancet (London, England) - 1 Jan 2000

Israel Elliot, Chinchilli Vernon M, Ford Jean G, Boushey Homer A, Cherniack Reuben, Craig Timothy J, Deykin Aaron, Fagan Joanne K, Fahy John V, Fish James, Kraft Monica, Kunselman Susan J, Lazarus Stephen C, Lemanske Robert F, Liggett Stephen B, Martin Richard J, Mitra Nandita, Peters Stephen P, Silverman Eric, Sorkness Christine A, Szefler Stanley J, Wechsler Michael E, Weiss Scott T, Drazen Jeffrey M

Abstract excerpt

BACKGROUND: The issue of whether regular use of an inhaled beta2-adrenergic agonist worsens airflow and clinical outcomes in asthma is controversial. Retrospective studies have suggested that adverse effects occur in patients with a genetic polymorphism that results in homozygosity for arginine (Arg/Arg), rather than glycine (Gly/Gly), at aminoacid residue 16 of the beta2-adrenergic receptor. However, the...

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PMID: 15500895
DOI: 10.1016/S0140-6736(04)17273-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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