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Article

Triiodothyroacetic acid has unique potential for therapy of resistance to thyroid hormone.

The Journal of clinical endocrinology and metabolism - 1 Jul 1995

Takeda T, Suzuki S, Liu R T, DeGroot L J

Abstract excerpt

3,5,3,'-Triiodothyroacetic acid (Triac) has been used in therapy of resistance to thyroid hormone on an empirical basis and appears beneficial in some studies. We observed that the T3 analogs, Triac and 3,5,3'-triiodothyropropionic acid (Triprop), have a higher affinity for the thyroid hormone receptor-beta 1 (TR beta 1) than does T3 (2.7- and 1.8-fold, respectively), whereas the affinities of the three compounds...

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PMID: 7608251
DOI: 10.1210/jcem.80.7.7608251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Triiodothyroacetic acid has unique potential for therapy of resistance to thyroid hormone.PMID 7608251Read ↗

In vitro effect of Triac on resistance to thyroid hormone receptor mutants: potential basis for therapy.Semantic proximity Read ↗

Therapeutic applications of thyroid hormone analogues in resistance to thyroid hormone (RTH) syndromes.Semantic proximity Read ↗

Effective TRIAC treatment of a THRβ-mutated patient with thyroid hormone resistance.Semantic proximity Read ↗

Amino acid substitutions of thyroid hormone receptor-beta at codon 435 with resistance to thyroid hormone selectively alter homodimer formation.Semantic proximity Read ↗

Therapeutic applications of thyroid hormone analogues.Semantic proximity Read ↗

Design and synthesis of complementing ligands for mutant thyroid hormone receptor TRbeta(R320H): a tailor-made approach toward the treatment of resistance to thyroid hormone.Semantic proximity Read ↗

Transcriptional activity of a mutant thyroid hormone receptor beta in a family with generalized resistance to thyroid hormone.Semantic proximity Read ↗

Two resistance to thyroid hormone mutants with impaired hormone binding.Semantic proximity Read ↗

Endocrine and neuropsychological assessment in a child with a novel mutation of thyroid hormone receptor: response to 12-month triiodothyroacetic acid (TRIAC) therapy.Semantic proximity Read ↗

Mutations of CpG dinucleotides located in the triiodothyronine (T3)-binding domain of the thyroid hormone receptor (TR) beta gene that appears to be devoid of natural mutations may not be detected because they are unlikely to produce the clinical phenotype of resistance to thyroid hormone.Semantic proximity Read ↗

A mutant thyroid hormone receptor beta 1 identified in a patient with resistance to thyroid hormone inhibits the activities of not only the wild-type TRs, but also other nuclear receptors.Semantic proximity Read ↗

Analysis of the roles of mutations in thyroid hormone receptor-β by a bacterial biosensor system.Semantic proximity Read ↗

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