Rapid, electrostatically assisted association of proteins.

doi:10.1038/nsb0596-427

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Article

Rapid, electrostatically assisted association of proteins.

Nature structural biology - 1 May 1996

Schreiber G, Fersht A R

Abstract excerpt

The rapid association of barnase and its intracellular inhibitor barstar has been analysed from the effects of mutagenesis and electrostatic screening. A basal association rate constant of 10(5) M(-1) s(-1) is increased to over 5 x 10(9) M(-1) s(-1) by electrostatic forces. The association betwee...

Topics

Bacterial Proteins
Electricity
Enzyme Inhibitors
Models, Chemical
Models, Molecular
Mutation
Osmolar Concentration
Protein Binding
Ribonucleases
Time Factors

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