Article
Cyclin A1 promoter hypermethylation in human papillomavirus-associated cervical cancer.
BMC cancer - 8 Mar 2006
Kitkumthorn Nakarin, Yanatatsanajit Pattamawadee, Kiatpongsan Sorapop, Phokaew Chureerat, Triratanachat Surang, Trivijitsilp Prasert, Termrungruanglert Wichai, Tresukosol Damrong, Niruthisard Somchai, Mutirangura Apiwat
Abstract excerpt
BACKGROUND: The aim of this study was to evaluate epigenetic status of cyclin A1 in human papillomavirus-associated cervical cancer. Y. Tokumaru et al., Cancer Res 64, 5982-7 (Sep 1, 2004)demonstrated in head and neck squamous-cell cancer an inverse correlation between cyclin A1 promoter hypermethylation and TP53 mutation. Human papillomavirus-associated cervical cancer, however, is deprived of TP53 function by a...
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