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Article

Frequency of Germline <i>PTEN</i> Mutations in Differentiated Thyroid Cancer

21 Mar 2011

Abstract excerpt

BACKGROUND: Differentiated thyroid cancer (DTC) is seen in 3%-10% of individuals carrying a germline PTEN mutation. Patients with PTEN mutations are at risk for additional neoplasms as are their affected offspring. However, the frequency of PTEN mutations among DTC cases has not been systematically analyzed. The objective of this study was to determine the frequency of PTEN mutations in an unselected group of...

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Identifiers

PMID: 21417916
DOI: 10.1089/thy.2010.0365

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