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Article

Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome.

JAMA - 22 Dec 2010

Bennett Kristi L, Mester Jessica, Eng Charis

Abstract excerpt

CONTEXT: Germline loss-of-function phosphatase and tensin homolog gene (PTEN) mutations cause 80% of Cowden syndrome, a rare autosomal-dominant disorder (1 in 200,000 live births), characterized by high risks of breast, thyroid, and other cancers. A large heterogeneous group of individuals with Cowden-like syndrome, who have various combinations of Cowden syndrome features but who do not meet Cowden syndrome...

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Topics

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Share to DNA Methylation
Share to Epigenesis, Genetic
Share to Gene Silencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ-Line Mutation

Share to Hamartoma Syndrome, Multiple

Share to PTEN Phosphohydrolase

Share to Rectal Neoplasms

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21177507
DOI: 10.1001/jama.2010.1877
PMCID: PMC3655326

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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