Article
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.
The Journal of biological chemistry - 1 Jun 2001
Sapkota G P, Kieloch A, Lizcano J M, Lain S, Arthur J S, Williams M R, Morrice N, Deak M, Alessi D R
Abstract excerpt
Peutz-Jeghers syndrome is an inherited cancer syndrome that results in a greatly increased risk of developing tumors in those affected. The causative gene is a protein kinase termed LKB1, predicted to function as a tumor suppressor. The mechanism by which LKB1 is regulated in cells is not known....
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