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Induction of oxidative DNA base damage in human skin cells by UV and near visible radiation

1 Dec 1997

Abstract excerpt

The premutagenic oxidative DNA base damage, 7,8-dihydro-8-oxoguanine, is induced in human skin fibroblasts by monochromatic radiation ranging from a UVB wavelength (312 nm) up to wavelengths in the near visible (434 nm). The oxidative damage is not generated by absorption of radiation in DNA but rather by activation of photosensitizers generating genotoxic singlet oxygen species. The spectrum for the yield of the...

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PMID: 9450485
DOI: 10.1093/carcin/18.12.2379

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