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Article

Evaluation of cytochrome P4502C9 metabolic activity with tolbutamide in CYP2C91 heterozygotes.

Clinical pharmacology and therapeutics - 1 Nov 2002

Lee Craig R, Pieper John A, Hinderliter Alan L, Blaisdell Joyce A, Goldstein Joyce A

Abstract excerpt

OBJECTIVES: Multiple single-nucleotide polymorphisms in the gene encoding cytochrome P450 (CYP) 2C9 have been identified, but the functional significance of the various putative defective genotypes in humans merits further study. METHODS: Using tolbutamide as a probe of CYP2C9 activity, we evalua...

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Identifiers

PMID: 12426520
DOI: 10.1067/mcp.2002.127913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12426520-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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