Article
Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient.
Current biology : CB - 1 Jul 1999
Riballo E, Critchlow S E, Teo S H, Doherty A J, Priestley A, Broughton B, Kysela B, Beamish H, Plowman N, Arlett C F, Lehmann A R, Jackson S P, Jeggo P A
Abstract excerpt
The major mechanism for the repair of DNA double-strand breaks (DSBs) in mammalian cells is non-homologous end-joining (NHEJ), a process that involves the DNA-dependent protein kinase [1] [2], XRCC4 and DNA ligase IV [3] [4] [5] [6]. Rodent cells and mice defective in these components are radiation-sensitive and defective in V(D)J-recombination, showing that NHEJ also functions to rejoin DSBs introduced during...
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