Visualizing Pneumococcal Infections in the Lungs of Live Mice Using Bioluminescent <i>Streptococcus pneumoniae</i> Transformed with a Novel Gram-Positive <i>lux</i> Transposon

Abstract excerpt

Animal studies with Streptococcus pneumoniae have provided valuable models for drug development. In order to monitor long-term pneumococcal infections noninvasively in living mice, a novel gram-positive lux transposon cassette, Tn4001 luxABCDE Km(r), that allows random integration of lux genes onto the bacterial chromosome was constructed. The cassette was designed so that the luxABCDE and kanamycin resistance...

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