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Article

Tissue-specific contributions of pneumococcal virulence factors to pathogenesis.

The Journal of infectious diseases - 1 Nov 2004

Orihuela Carlos J, Gao Geli, Francis Kevin P, Yu Jun, Tuomanen Elaine I

Abstract excerpt

We assessed the ability of Streptococcus pneumoniae mutants deficient in either choline binding protein A (CbpA), pneumolysin (Pln), pyruvate oxidase (SpxB), autolysin (LytA), pneumococcal surface protein A, or neuraminidase A (NanA) to replicate in distinct anatomical sites and translocate from one site to the next. Intranasal, intratracheal, and intravenous models of disease were assessed in 4-week-old BALB/cJ...

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Identifiers

PMID: 15478073
DOI: 10.1086/424596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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