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BrkA Protein ofBordetella pertussisInhibits the Classical Pathway of Complement after C1 Deposition

1 May 2001

Abstract excerpt

Bordetella pertussis produces a 73-kDa protein, BrkA (Bordetella resistance to killing), which inhibits the bactericidal activity of complement. In this study we characterized the step in the complement cascade where BrkA acts, using three strains: a wild-type strain, a strain containing an insertional disruption of brkA, and a strain containing two copies of the brkA locus. Following incubation with 10% human...

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PMID: 11292725
DOI: 10.1128/iai.69.5.3067-3072.2001

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