The peptide antibiotic microcin B17 induces double-strand cleavage of DNA mediated by E. coli DNA gyrase.

doi:10.1002/j.1460-2075.1991.tb07969.x

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Article

The peptide antibiotic microcin B17 induces double-strand cleavage of DNA mediated by E. coli DNA gyrase.

The EMBO journal - 1 Feb 1991

Vizán J L, Hernández-Chico C, del Castillo I, Moreno F

Abstract excerpt

Microcin B17 (MccB17) is a bactericidal peptide antibiotic which inhibits DNA replication. Two Escherichia coli MccB17 resistant mutants were isolated and the mutations were shown to map to 83 min of the genetic map. Cloning of the mutations and Tn5 insertional analysis demonstrated that they wer...

Topics

Amino Acid Sequence
Anti-Bacterial Agents
Bacteriocins
Cloning, Molecular
DNA Replication
DNA Topoisomerases, Type II
DNA, Bacterial
Drug Resistance, Microbial
Escherichia coli
Genes, Bacterial
Kinetics
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Insertional

Phenotype

Restriction Mapping

Sequence Homology, Nucleic Acid

Topoisomerase II Inhibitors

Transduction, Genetic

Source

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Identifiers

PMID: 1846808
DOI: 10.1002/j.1460-2075.1991.tb07969.x
PMCID: PMC452668

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1846808-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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