Article
Control of spermatogenesis in mice by the cyclin D-dependent kinase inhibitors p18(Ink4c) and p19(Ink4d).
Molecular and cellular biology - 1 May 2001
Zindy F, den Besten W, Chen B, Rehg J E, Latres E, Barbacid M, Pollard J W, Sherr C J, Cohen P E, Roussel M F
Abstract excerpt
Male mice lacking both the Ink4c and Ink4d genes, which encode two inhibitors of D-type cyclin-dependent kinases (Cdks), are infertile, whereas female fecundity is unaffected. Both p18(Ink4c) and p19(Ink4d) are expressed in the seminiferous tubules of postnatal wild-type mice, being largely confi...
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