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Article

Disease model: human aging.

Trends in molecular medicine - 1 Apr 2001

Kuro-o M

Abstract excerpt

Very little is known about the molecular mechanisms of human aging. This, at least in part, derives from a paucity of appropriate animal models of aging. Until recently, the senescence-accelerated mouse was the only mammalian model of aging. However, novel mouse models that exhibit multiple aging phenotypes have been developed in the past few years by disruption of the klotho gene, the telomerase gene and the...

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PMID: 11286943
DOI: 10.1016/s1471-4914(01)01921-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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