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Article

Alanine substitutions in calmodulin-binding peptides result in unexpected affinity enhancement.

Journal of molecular biology - 26 Apr 1996

Montigiani S, Neri G, Neri P, Neri D

Abstract excerpt

Calmodulin is a calcium-binding protein that regulates a wide range of enzymes. It is also one of the few examples of a small protein capable of binding to peptides with very high affinity, and is therefore an interesting candidate for biotechnological applications and a good model system for stu...

Topics

Alanine
Amino Acid Sequence
Animals
Calmodulin
Calmodulin-Binding Proteins
Kinetics
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Sequence Data
Mutation
Myosin-Light-Chain Kinase
Peptides

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Protein Binding

Rabbits

Source

Identifiers

PMID: 8613992
DOI: 10.1006/jmbi.1996.0229

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8613992-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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