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Article

A sequence change (Arg158Gln) in the leucine zipper-like motif region of the MYOC/TIGR protein.

Journal of human genetics - 1 Jan 2001

Mabuchi F, Yamagata Z, Kashiwagi K, Ishijima K, Tang S, Iijima H, Tsukahara S

Abstract excerpt

The myocilin/trabecular meshwork-inducible glucocorticoid response (MYOC/TIGR) gene was identified as a gene that caused open angle glaucoma (OAG). Single-strand conformation polymorphism analysis and subsequent sequence analysis were performed for the MYOC/TIGR gene in 120 unrelated Japanese OAG patients with increased intraocular pressure (IOP), 116 unrelated OAG patients without increased IOP, and 106...

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Source

Identifiers

PMID: 11281418
DOI: 10.1007/s100380170114

Genes

MYOC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A sequence change (Arg158Gln) in the leucine zipper-like motif region of the MYOC/TIGR protein.PMID 11281418Read ↗

Clinical phenotype of a Japanese family with primary open angle glaucoma caused by a Pro370Leu mutation in the MYOC/TIGR gene.Semantic proximity Read ↗

[Study on MYOC/TIGR gene mutations in primary open-angle glaucoma].Semantic proximity Read ↗

GLC1A mutations point to regions of potential functional importance on the TIGR/MYOC protein.Semantic proximity Read ↗

Keeping an Eye on Myocilin: A Complex Molecule Associated with Primary Open-Angle Glaucoma SusceptibilitySemantic proximity Read ↗

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Association of a single nucleotide polymorphism in the TIGR/MYOCILIN gene promoter with the severity of primary open-angle glaucoma.Semantic proximity Read ↗

Novel TIGR/MYOC mutations in families with juvenile onset primary open angle glaucoma.Semantic proximity Read ↗

[Study on the gene mutation of TIGR in primary open angle glaucoma, their relatives and normal controls in Chongqing].Semantic proximity Read ↗

[Study on single nucleotide polymorphism of TIGR gene in primary open-angle glaucoma patients].Semantic proximity Read ↗

Recurrent Mutations in a Single Exon Encoding the Evolutionarily Conserved Olfactomedin-Homology Domain of TIGR in Familial Open-Angle GlaucomaSemantic proximity Read ↗

Sequence analysis of MYOC and CYP1B1 in a Chinese pedigree of primary open-angle glaucoma.Semantic proximity Read ↗

Heredity in primary open-angle glaucoma.Semantic proximity Read ↗

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