Article
Age-dependent prevalence of mutations at the GLC1A locus in primary open-angle glaucoma.
American journal of ophthalmology - 1 Aug 2000
Shimizu S, Lichter P R, Johnson A T, Zhou Z, Higashi M, Gottfredsdottir M, Othman M, Moroi S E, Rozsa F W, Schertzer R M, Clarke M S, Schwartz A L, Downs C A, Vollrath D, Richards J E
Abstract excerpt
PURPOSE: To screen a population with primary open-angle glaucoma for mutations in the gene that encodes the trabecular meshwork inducible glucocorticoid response protein (TIGR), also known as myocilin (MYOC). METHODS: Ophthalmologic information was collected for study subjects with primary open-angle glaucoma and their relatives. Mutation screening of 74 primary open-angle glaucoma probands was conducted by...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Aging
- Child
- Cytoskeletal Proteins
- DNA Mutational Analysis
- DNA Primers
- Eye Proteins
- Female